The total area of the Province is 28 400 square kilometers. The climate is typically continental, arid and partly subtropical.

The province has a population 2 029 000 with more than 73 % living in rural areas.

Kashkadarya is divided into 14 administrative districts with Karshi as its administrative Center. The town of Karshi has a population of 177 000. Other important towns are Shakhrisabz, Kitab, Kasan, Mubarekh, Yakkabad, Gusar and Kamashi.

There are 14 joint ventures with foreign investment functioning in the Province.